Influence of Microbubble Shell Chemistry on the Destruction Threshold of Ultrasound Contrast Agent Microbubbles

Michal Mleczko, Stephen M. Dicker, Steven P. Wrenn, Georg Schmitz

31st In­ter­na­tio­nal Sym­po­si­um on Acousti­cal Ima­ging, 2011. pp. 91-101, doi: 10.1007/978-94-007-2619-2_10


The destruction threshold of ultrasound contrast agents is an important parameter for safety and applications in targeted drug delivery. Since this threshold is a function of the chemical composition of lipid-shelled microbubbles, adjustment of this composition may allow tuning of the destruction threshold. To attain this goal, this study presents a framework for the analysis of the destruction threshold. A method for the theoretical determination of this threshold is presented. Theoretical results are subsequently validated by experiments, yielding a linear dependence between shell viscosity and elasticity and DSPE-PEG2000 concentration.


tags: Destruction, functionalised lipid, inertial cavitation, material parameters, microbubbles, ultrasound contrast agent